Cerebrospinal fluid biomarker profiling in corticobasal degeneration: Application of the AT(N) and other classification systems

IntroductionTotal tau (τT), phosphorylated (τP-181) and amyloid beta (Aβ42) are cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD). There is no consensus on the interpretation criteria these biomarkers. The aim this study was to apply three different sets for CSF AD biomarker in a cohort corticobasal degeneration (CBD) patients.MethodSForty patients fulfilling diagnostic “probable CBD” were included. AT(N), BIOMARKAPD/ABSI τP-181/Aβ42 ratio applied.ResultsThe AT(N) categorized 50% as AD, 62.5% harboring pathology. τP- 181/Aβ42 ~40% AD.DiscussionUse produces diverse results. pathology common “probable” CBD criteria. may have suboptimal positive predictive value. A regarding pivotal.